Meta-analyses of Total and Individual Fructose-containing Sugars and Incident Cardiometabolic Disease

Summary

Since uncontrolled observational studies first linked fructose to the epidemic of obesity almost a decade ago, it has become a focus of intense concern regarding its role in the obesity epidemic and increasing burden of cardiometabolic disease. Despite the uncertainties in the evidence, international health organizations have cautioned against moderate to high intakes fructose-containing sugars, especially those from sugar sweetened beverages (SSBs). To improve the evidence on which nutrition recommendations are based, the investigators propose to study of the role of fructose-containing sugars in the development of overweight/obesity, diabetes, hypertension, gout, and cardiovascular disease, by undertaking a series of systematic syntheses of the available prospective cohort studies. Prospective cohort studies have the advantage of relating "real world" intakes of sugars to clinically meaningful disease endpoints over long durations of follow-up. The findings generated by this proposed knowledge synthesis will help improve the health of consumers through informing recommendations for the general public, as well as those at risk of diabetes and cardiovascular disease.

Conditions

• Overweight
• Obesity
• Dyslipidemia
• Hyperlipidemia
• Diabetes
• Prediabetes
• Dysglycemia
• Gout
• Hypertension
• Metabolic Syndrome
• Coronary Heart Disease
• Cardiovascular Disease

Sponsors & Collaborators

• Calorie Control Council

  collaborator OTHER

• Canada Research Chairs Endowment of the Federal Government of Canada

  collaborator OTHER_GOV

• Canadian Institutes of Health Research (CIHR)

  collaborator OTHER_GOV

• John Sievenpiper

  lead OTHER

Principal Investigators

• John L Sievenpiper, MD, PhD · Department of Pathology and Molecular Medicine, McMaster University and Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital

• Russell J de Souza, ScD, RD · Department of Epidemiology and Biostatistics, McMaster University and Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital

• David JA Jenkins, MD, PhD, DSc · Department of Nutritional Sciences and Medicine, University of Toronto and Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital

Eligibility

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2012-05-31

Primary Completion

2014-09-30

Completion

2016-09-30

Countries

• Canada

Study Locations