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Meta-analyses of the Effect of Important Food Sources of Sugars on Cardiometabolic Risk Factors

NCT02716870 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 1

Last updated 2020-06-25

No results posted yet for this study

Summary

Fructose-containing sugars have been implicated in the epidemics of obesity, diabetes and related cardiometabolic disorders. This view is supported by lower quality evidence from ecological observations, animal models, and select human trials. Higher level evidence from controlled trials and prospective cohort studies have been inconclusive. Whether sugars contribute to cardiometabolic complications independent of their calories remains unclear. To address the uncertainties, the investigators propose to conduct a series of systematic reviews and meta-analyses of the totality of the evidence from controlled trials to distinguish the contribution of fructose-containing sugars from that of energy in the development of markers of cardiometabolic risk. The findings generated by this proposed knowledge synthesis will help improve the health of consumers through informing evidence-based guidelines and improving health outcomes by educating healthcare providers and patients, stimulating industry innovation, and guiding future research design.

Conditions

Interventions

OTHER

Fructose-containing Sugars

An intervention in which calories from fructose-containing sugars are substituted, added, or subtracted in the diet

Sponsors & Collaborators

  • Canadian Diabetes Association

    collaborator OTHER

  • The Physicians' Services Incorporated Foundation

    collaborator OTHER

  • Banting & Best Diabetes Centre

    collaborator OTHER

  • University of Toronto

    lead OTHER

Principal Investigators

  • John L Sievenpiper, MD,PhD,FRCPC · University of Toronto

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-06-30
Primary Completion
2020-12-31
Completion
2020-12-31

Countries

  • Canada

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02716870 on ClinicalTrials.gov