Prediabetes is a metabolic condition with blood glucose levels above normal but below diabetes thresholds, indicating high risk of progression to type 2 diabetes and cardiovascular disease.
A JAMA Network Open study found high-dose vitamin D may reduce progression from prediabetes to type 2 diabetes in people with certain vitamin D receptor genotypes. In participants with ApaI CC or AC alleles, risk fell 19% versus placebo, while no reduction was seen in those with ApaI AA alleles.
Research in the United Kingdom found that preventing type 2 diabetes cut care-related greenhouse gas emissions by about 67%, while well-controlled disease was linked to 21% lower emissions than uncontrolled diabetes.
Recent studies demonstrate that blood-based biomarkers combined with AI can predict dementia risk 25 years early in women, identify liver cancer-prone environments with 93% accuracy, and classify prediabetes risk groups with 90% accuracy.
Health and Human Services Secretary Robert F. Kennedy Jr. announced plans to review the safety of ultra-processed foods, criticizing the GRAS exemption that allows companies to verify ingredient safety without FDA oversight since 1997.
Novo Nordisk sues telehealth companies over compounded weight-loss drugs as employers explore AI-based alternatives to costly GLP-1 medications. About 1 in 8 Americans now take GLP-1 drugs for weight loss or diabetes.
Multiple Indian drugmakers begin selling generic versions of Ozempic and Wegovy following March patent expiration, with prices 50-60% below branded counterparts. The launches signal global pricing shifts as Novo Nordisk faces patent losses across multiple markets.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07598773 |
BETA: Study in Prediabetes Type 2 Diabetes |
ENROLLING_BY_INVITATION | |
| NCT07558525 |
Evaluation of Chiglitazar Sodium With Lifestyle Intervention for Reversing Prediabetes |
NOT_YET_RECRUITING | NA |
| NCT07553325 |
Risk-informed Shared-decision Making Engagement Strategy for Patients With Prediabetes |
NOT_YET_RECRUITING | NA |
| NCT07546409 |
Effects of Exogenous Ketones on Cognitive Function in Older Adults With Prediabetes? |
ACTIVE_NOT_RECRUITING | NA |
| NCT07536256 |
Community Connections Through Native Hawaiian Cultural Values to Strengthen Youth Resilience, Health, and Well-Being |
RECRUITING | NA |
| NCT07529366 |
Pharmacist-Led Continuous Glucose Monitoring for Prediabetes |
RECRUITING | |
| NCT07525622 |
Basic Carbohydrate Counting in Prediabetes |
RECRUITING | NA |
| NCT07506577 |
Impact of Saccharin and Acesulfame-Potassium on Glycemia |
COMPLETED | NA |
| NCT07506564 |
Acute Impact of Non-Sugar Sweeteners (Sucralose and Aspartame) |
COMPLETED | NA |
| NCT07505745 |
MOTS-c for Improving Insulin Sensitivity in Adults With Prediabetes and Overweight/Obesity |
RECRUITING | PHASE2 |
