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Acute Effect of Fructose on Lipid Metabolism and Gender Differences

NCT00620360 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 18

Last updated 2012-02-24

No results posted yet for this study

Summary

It has been widely documented that fructose overfeeding increases plasma triglycerides and hepatic de novo lipogenesis, and impairs insulin sensitivity in healthy male volunteers. The effect of gender on the metabolic responses to fructose remains an important open question, however.

The objective of this study is to compare the effect of an acute oral fructose load on carbohydrate and lipid metabolism in healthy young males and females.

Conditions

  • Lipid Metabolism

Interventions

DIETARY_SUPPLEMENT

fructose

acute administration of 4 times 0.3g fructose/kg lean body mass

DIETARY_SUPPLEMENT

Fructose

acute administration of 4 times 0.3 g/kg fat-free mass oral fructose

Sponsors & Collaborators

  • University of Lausanne

    lead OTHER

Principal Investigators

  • Luc Tappy, MD · University of Lausanne

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2008-01-31
Primary Completion
2008-12-31
Completion
2008-12-31

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00620360 on ClinicalTrials.gov