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The Metabolic Effects of a High Fructose Versus a High Glucose Diet in Overweight Men

NCT01050140 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 32

Last updated 2012-07-04

No results posted yet for this study

Summary

Dietary consumption of fructose has increased by nearly 50% since 1960.

A high fructose diet (HFrD) results in greater visceral adiposity and systemic insulin resistance than a high glucose diet. The effects of fructose on liver fatty acid and ATP stores, systemic oxidative stress and cardiovascular status are not fully known.

Conditions

  • Hepatic Fatty Acid Metabolism
  • Systemic Insulin Resistance
  • Oxidative Stress
  • Cardiovascular Status

Interventions

DIETARY_SUPPLEMENT

high sugar diet

25% of dietary energy from fructose or glucose

Sponsors & Collaborators

  • University of Nottingham

    lead OTHER

Principal Investigators

  • Ian A Macdonald, PhD · School of Biomedical Sciences, Nottingham University, UK

  • Richard D Johnston, MRCP · School of Biomedical Sciences, Nottingham University, UK

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-01-31
Primary Completion
2010-12-31
Completion
2011-04-30

Countries

  • United Kingdom

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01050140 on ClinicalTrials.gov