Hypertension is a chronic condition characterized by persistently elevated arterial blood pressure. It is often asymptomatic but significantly increases the risk of stroke, myocardial infarction, heart failure, kidney disease, and premature death. Management combines lifestyle modification and antihypertensive medications.
Alnylam reported Q4 2025 adjusted EPS of $1.25, beating estimates, while revenue of $1.10 billion missed consensus despite 85% growth. Amvuttra sales surged 189% to $826.6 million. The stock fell 4.1% after the mixed results.
Biotech funding roundup: $8M CIRM grant to Siren, $3.5M pre-seed for Claryx, Syntax Bio's $14.4M Series A, €80M Novo Nordisk Foundation programme, and Appili's NIAID contract termination.
New research: any cardiometabolic risk factor justifies MASLD screening in overweight adults, and MASLD independently worsens sepsis, bleeding, and other outcomes in hospitalized Crohn's disease patients.
Recent Rethinking Clinical Trials Grand Rounds sessions covered the COMPARE-Pediatric IBD study, a hypertension self-management texting intervention for Black Veterans, and the upcoming Pediatric Trials Network presentation.
A study finds that white matter disease detected on CT scans signals a higher risk for stroke or dementia compared to MRI-only findings. CT-detected WMD may represent more advanced cerebrovascular injury, highlighting the need for modality-specific interpretation of incidentally discovered brain abnormalities.
Australian and US regulators have warned about sexual enhancement and honey products containing undeclared prescription medicines, prompting recalls and safety alerts. UK regulators also caution about underreported drug-herb interactions and herb-induced liver injury.
Hematologic cancer survivors face elevated CVD risk and fourfold higher heart failure risk. Cardiac screening is low among cardiotoxic treatment recipients. A trial found simple risk assessment may suffice.
A study published in Menopause found that initiating hormone therapy after age 65 is associated with increased risks for any cancer and cerebrovascular accidents. The analysis of 83,147 women also showed elevated hazards for cancer and vascular events among those who initiated HT at ages 50 to 65.
Recent studies show that resistance training lowers cardiovascular disease risk in women, muscular strength is tied to lower mortality in older women, and both weekend warrior and regular exercise patterns reduce mortality in patients with hypertension.
A case report describes eight-and-a-half syndrome in a 71-year-old man with hypertension and ischemic heart disease who presented with acute neurological deficits. MRI revealed an acute pontine infarction causing the characteristic triad of horizontal gaze palsy, internuclear ophthalmoplegia, and facial weakness.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07780500 |
REFOCUS-HTN US-WEST: A Data Infrastructure to Characterize Individuals With Hypertension |
RECRUITING | |
| NCT07778771 |
CEEEC-II: A 12-Week Physical and Cognitive Enrichment Extension Study in Older Stroke Survivors With Multimorbidity |
NOT_YET_RECRUITING | NA |
| NCT07777237 |
Emergency Department-Initiated Team-Based Care for Severe Hypertension |
NOT_YET_RECRUITING | NA |
| NCT07773272 |
Cardiovascular-kidney-metabolic (CKM)-Guided Therapy for Patients After Acute Coronary Syndrome |
RECRUITING | |
| NCT07771504 |
Health Coaching Added to Standard Therapy for Hypertension: Blood Pressure and Quality of Life |
COMPLETED | NA |
| NCT07770477 |
Comparison of Office and Cuffless Ambulatory Blood Pressure-Guided Management in Patients With Hypertension |
NOT_YET_RECRUITING | NA |
| NCT07768865 |
Arterial Stiffness in Children and Young People With Hypertension and Chronic Kidney Disease |
RECRUITING | |
| NCT07762456 |
BATHE-Family Medicine |
COMPLETED | NA |
| NCT07760623 |
Common Carotid Artery-Renal Artery-Femoral Artery Survey for Hypertension |
NOT_YET_RECRUITING | |
| NCT07758634 |
A Trial Evaluating Safety, Tolerability and Efficacy of CTX340 in Participants With Hypertension |
RECRUITING | PHASE1/PHASE2 |
