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Fructose: Substrate, Stimulus, or Both?

NCT04168372 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 35

Last updated 2026-04-24

No results posted yet for this study

Summary

This objective of this study is to use sensitive methodology under controlled conditions to investigate the mechanisms by which fructose consumption contributes to excess fatty acid synthesis and elevations in blood glucose levels following consumption of meals containing fructose.

Conditions

Interventions

OTHER

High fructose, fructose labeled meal

Liquid meal containing high fructose (16% of energy), labeled with 2-13C fructose

OTHER

High fructose, pyruvate labeled meal

Liquid meal containing high fructose (16% of energy), labeled with 2-13C pyruvate

OTHER

Low fructose, fructose labeled meal

Liquid meals containing low fructose (6% of energy), labeled with 2-13C fructose

OTHER

Low fructose, pyruvate labeled meal

Liquid meal containing low fructose (6% of energy), labeled with 2-13C pyruvate

Sponsors & Collaborators

  • Touro University, California

    lead OTHER

Principal Investigators

  • Jean-Marc Schwarz, PhD · Touro University, California

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
20 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-09-15
Primary Completion
2026-05-31
Completion
2026-12-20

Countries

  • United States

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04168372 on ClinicalTrials.gov