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Meta-analysis of Low-calorie Sweetened Beverages and Cardiometabolic Outcomes

NCT04245826 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 1

Last updated 2020-02-25

No results posted yet for this study

Summary

We propose to conduct a systematic literature review and meta-analysis to assess the association of low-calorie sweetened beverages (LCSBs) on cardiometabolic outcomes in prospective cohort studies. We will be using methodological approaches (change in LCSBs intake, and/or substitution analysis) that attempt to overcome the issue of reverse causality associated with studies of LCSBs and cardiometabolic disease. Ten cardiometabolic outcomes will be assessed:

1. Global adiposity - body weight
2. Global adiposity - BMI
3. Global adiposity - body fat
4. Abdominal adiposity - waist circumference
5. Overweight/obesity incidence
6. Metabolic syndrome incidence
7. Type 2 diabetes incidence
8. Cardiovascular disease incidence
9. Cardiovascular disease mortality
10. Total mortality

Conditions

Interventions

OTHER

Change in LCSBs Intake

Effect of changing LCSBs intake

OTHER

Substitute LCSBs for SSBs or Water

Effect of substituting LCSBs for SSBs or Water

Sponsors & Collaborators

  • University of Toronto

    lead OTHER

Principal Investigators

  • John L Sievenpiper, MD,PhD,FRCPC · University of Toronto

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-05-16
Primary Completion
2020-03-01
Completion
2020-05-01

Countries

  • Canada

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04245826 on ClinicalTrials.gov