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Assessments of Metabolic Responses to Acute Oral Administration of Sucrose, Glucose, and Fructose

NCT06799715 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2026-05-01

No results posted yet for this study

Summary

This project aims to compare the acute metabolic effects of the three sweeteners sucrose, glucose, and fructose on GI hormones (GLP-1, PYY, CCK, and ghrelin).

Furthermore, glycemic control, erythritol and xylitol concentrations, blood coagulation function , blood lipids, uric acid, high-sensitive C-reactive protein (hsCRP), complete blood count, gastric emptying, appetite-related sensations, and GI symptoms will be investigated.

Conditions

  • Gastrointestinal Hormones
  • Glycemic Control
  • Blood Coagulation Function
  • Gastric Emptying

Interventions

DIETARY_SUPPLEMENT

Sucrose

33.5g sucrose dissolved in 300mL tap water

DIETARY_SUPPLEMENT

Glucose

33.5g glucose dissolved in 300mL tap water

DIETARY_SUPPLEMENT

Fructose

33.5g fructose dissolved in 300mL tap water

DIETARY_SUPPLEMENT

Water

300mL water

Sponsors & Collaborators

  • University Hospital, Basel, Switzerland

    lead OTHER

Principal Investigators

  • Anne Christin Meyer-Gerspach, PD, PhD · St. Clara Research Ltd.

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-02-06
Primary Completion
2026-09-30
Completion
2026-09-30

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06799715 on ClinicalTrials.gov