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Effects of Almonds on Vascular Reactivity in Patients With Coronary Artery Disease

NCT00782015 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 45

Last updated 2017-04-28

No results posted yet for this study

Summary

This is a study of the effects of 3 oz almonds added daily to a National Cholesterol Education Program Therapeutic Lifestyle Changes (TLC) diet in improving endothelial function in patients with Coronary Artery Disease. The study seeks to determine if these effects are mediated via an increase in Nitric Oxide synthesis and reductions in dyslipidemia and systemic inflammation.

Vascular reactivity will be assessed via flow mediated dilation with endothelium-independent and hyperemic flow measured in the right brachial artery by non-invasive 2-dimensional and Doppler ultrasound. Serum will be collected and analyzed for biomarkers of dyslipidemia, inflammation, endothelial function, vascular reactivity and oxidative stress.

Conditions

Interventions

DIETARY_SUPPLEMENT

Almonds

3 oz. of almonds per day, supplied as 1 oz. snack packs to be consumed for 6 weeks.

DIETARY_SUPPLEMENT

Placebo Comparator:

NCEP Step 2 diet

Sponsors & Collaborators

  • Boston University

    collaborator OTHER

  • Tufts University

    lead OTHER

Principal Investigators

  • Jeffrey B Blumberg, PhD · HNRCA Tufts University

  • Joseph Vita, MD · Boston University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
20 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2008-10-31
Primary Completion
2011-01-31
Completion
2011-01-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00782015 on ClinicalTrials.gov