Meta-analyses of Dietary Pulses and Cardiometabolic Risk

Summary

Dietary pulses, more commonly known as "legumes", are generally recognized as healthy components of the diet. Canada's Food Guide encourages consumptions of meat alternatives, such as beans "more often"; and the dietary guidelines for Americans both recommend consumption of 3 cups of legumes per week. However, there still remain insufficient information on the usefulness of these foods in protecting heart health. To improve evidence-based guidance for non-oil-seed pulse recommendations, the investigators propose to conduct a systematic review of clinical studies to assess the effect of eating pulses in exchange for other foods on measures of heart disease risk and blood sugar control in humans. The systematic review process allows the combining of the results from many small studies in order to arrive at a pooled estimate, similar to a weighted average, of the true effect. The investigators will be able to explore whether eating pulses has different effects between men and women, in different age groups, in people with high or normal sugar or blood fat levels, and whether or not the effect of pulses depends on how much/often they are eaten. The findings of this proposed knowledge synthesis will help improve the health of Canadians through informing recommendations for the general public, as well as those at risk of heart disease and diabetes.

Conditions

• Dyslipidemia
• Diabetes
• Prediabetes
• Dysglycemia
• Overweight
• Obesity
• Hypertension
• Metabolic Syndrome
• Cardiovascular Disease

Interventions

OTHER

Dietary pulses

beans, peas, chickpeas, or lentils in whole or flour form

Sponsors & Collaborators

• Canadian Institutes of Health Research (CIHR)

  collaborator OTHER_GOV

• Canada Research Chairs Endowment of the Federal Government of Canada

  collaborator OTHER_GOV

• Pulse Canada

  collaborator OTHER

• John Sievenpiper

  lead OTHER

Principal Investigators

• John L Sievenpiper, MD, PhD · Department of Pathology and Molecular Medicine, McMaster University and Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital

• Russell J de Souza, ScD, RD · Department of Epidemiology and Biostatistics, McMaster University and Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital

• Joseph Beyene, PhD · Department of Epidemiology and Biostatistics, McMaster University

• David JA Jenkins, MD, PhD, DSc · Department of Nutritional Sciences and Medicine, University of Toronto and Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital

• Cyril WC Kendall, PhD · Department of Nutritional Sciences, University of Toronto and College of Pharamcy and Nutrition, University of Saskatchewan

Eligibility

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2012-03-31

Primary Completion

2015-12-31

Completion

2015-12-31

Countries

• Canada

Study Locations