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Influence of Protein Hydrolysis on Dietary Protein Digestibility and Metabolism in Healthy Subjects

NCT00873951 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 26

Last updated 2025-10-06

No results posted yet for this study

Summary

Hydrolysis of dietary protein may impact their gastrointestinal kinetics and further metabolism. The primary goal of this work was to measure the metabolic fate of intact or hydrolyzed protein using a protein of good nutritional quality, i.e., casein. A second aim of this study was to assess the true ileal digestibility of dietary protein using different methods including the hydrolyzed casein method and to measure its possible effect on endogenous intestinal N losses in humans.

Conditions

  • Healthy

Interventions

OTHER

Intestinal and metabolic exploration

Subjects are studied for 8h following the ingestion of a standard meal containing 15% of energy as protein. Intestinal, blood and urine are collected at regular intervals.

DIETARY_SUPPLEMENT

15N-labelled intact casein

standard mixed meal containing 15% of energy as 15N-labelled intact casein

DIETARY_SUPPLEMENT

15N-labelled hydrolyzed casein

standard mixed meal containing 15% of energy as 15N-labelled hydrolyzed casein

DIETARY_SUPPLEMENT

mixture of AA

standard mixed meal containing 15% of energy as a mixture of AA mimicking the composition of casein but devoid in serine

Sponsors & Collaborators

  • Riddet Institute

    collaborator UNKNOWN

  • Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2006-01-31
Primary Completion
2006-11-30
Completion
2008-01-31

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00873951 on ClinicalTrials.gov