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Effect of a Novel Sweetener on the pH of Dental Plaque.

NCT00739778 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 24

Last updated 2008-12-18

No results posted yet for this study

Summary

Bacteria that live in the mouth can digest fermentable carbohydrates such as sucrose, fructose, and glucose to make acid. This acid can cause demineralization of the tooth and lead to dental caries or decay. Noncariogenic carbohydrate sweeteners, such as sugar alcohols, can be used to replace fermentable carbohydrates in foods, thereby decreasing the risk of caries. In order for a sweetener to be labeled as a noncariogenic sweetener, the FDA requires that when present in food, the food should not lower the dental plaque pH below 5.7 either during or up to 30 minutes after consumption. The purpose of this study is to determine whether a new developmental sweetener can be fermented by the bacteria in the mouth and lead to acid production. This will be done by measuring the pH of dental plaque following consumption of the sweetener.

Conditions

  • Dental Caries

Interventions

OTHER

food - novel sweetener

concentration to be isosweet with 4.7% sucrose

OTHER

food vehicle blank

water blank

OTHER

food - sweetener, positive control

4.7% sucrose in water

OTHER

food - sweetener, negative control

non-cariogenic sweetener at concentration isosweet with 4.7% sucrose

Sponsors & Collaborators

  • Cargill

    lead INDUSTRY

Principal Investigators

  • Max Goodson, DDS, PhD · The Forsyth Institute

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2008-08-31
Primary Completion
2008-12-31
Completion
2008-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00739778 on ClinicalTrials.gov