Microbiome and Non-caloric Sweeteners in Humans

Summary

Non-caloric sweeteners are common food supplements consumed by millions worldwide as means of combating weight gain and diabetes, by retaining sweet taste without increasing caloric intake. While they are considered safe, there is increasing debate regarding their potential role in contributing to metabolic derangements in some humans. The investigators recently demonstrated that non-caloric sweeteners consumption could induce glucose intolerance in mice and, in preliminary experiments, in distinct human subsets, by functionally altering the gut microbiome, and that the gut microbiome plays an important role in mediating differential glucose responses to identical foods. The proportion of the human population that is susceptible to glucose intolerance induced by non-caloric sweeteners, the common factors that are shared between these individuals and whether and how the microbiome promotes the metabolic derangements remain to be addressed.

Conditions

• Glucose Intolerance
• Glucose, Low Blood
• Glucose, High Blood

Interventions

DIETARY_SUPPLEMENT

Glucose

Daily consumption of 5g of glucose, for 14 days.

DIETARY_SUPPLEMENT

Aspartame

Daily consumption of six commercially available sachets containing aspartame and glucose as bulking agent (1g each sachet), for 14 days.

DIETARY_SUPPLEMENT

Sucralose

Daily consumption of six commercially available sachets containing sucralose and glucose as bulking agent (1g each sachet), for 14 days.

DIETARY_SUPPLEMENT

Saccharin

Daily consumption of six commercially available sachets containing saccharine and glucose as bulking agent (1g each sachet), for 14 days.

DIETARY_SUPPLEMENT

Stevia

Daily consumption of six commercially available sachets containing Stevia and glucose as bulking agent (1g each sachet), for 14 days.

OTHER

No Supplement

Follow up without any dietary supplementation.

Sponsors & Collaborators

• Weizmann Institute of Science

  lead OTHER

Principal Investigators

• Eran Elinav · Weizmann Institute of Science

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

70 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2017-02-19

Primary Completion

2020-08-01

Completion

2021-01-01

Countries

• Israel

Study Locations