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The Effect of Artificial Sweeteners (AFS) on Sweetness Sensitivity, Preference and Brain Response in Adults

NCT02335021 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 97

Last updated 2019-09-26

No results posted yet for this study

Summary

The purpose of this study is to investigate the effects of dietary exposure to artificial sweeteners on taste sensitivity, preference and brain response in adults. The investigators hypothesize that dietary exposure to artificial sweeteners (sucralose) will decrease sensitivity to taste, shift preference of sweet and savory taste to a higher dose, and reduce brain response in amygdala to sweet taste compared to sucrose.

Conditions

Interventions

DIETARY_SUPPLEMENT

Sucralose

2 packets per 12 fl oz

DIETARY_SUPPLEMENT

Sucrose

equisweet to sucralose

DIETARY_SUPPLEMENT

Sucralose + maltodextrin

sucralose plus equicaloric (to sucrose) maltodextrin

DIETARY_SUPPLEMENT

Sucralose + Sucrose

half the amount of sucralose plus equicaloric sucrose

Sponsors & Collaborators

  • Yale University

    lead OTHER

Principal Investigators

  • Dana M Small · Yale University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
23 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-01-01
Primary Completion
2019-04-24
Completion
2019-04-24

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02335021 on ClinicalTrials.gov