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Interactions of Human Gut Microbiota With Intestinal Sweet Taste Receptors

NCT03032640 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 102

Last updated 2023-02-02

No results posted yet for this study

Summary

The purpose of this study is to collect data to examine whether short-term consumption of non-caloric artificial sweeteners (NCASs), such as saccharin, can lead to changes in blood sugar levels and in the composition of the bacteria in the large intestine.

Conditions

Interventions

OTHER

Oral Glucose Tolerance Test (OGTT)

Once we test the fasting plasma glucose (after an overnight fast), subject will receive a 75g glucose beverage they will have to drink within 5 minutes. Then after drinking the beverage, 8 blood samples will be collected through the IV catheter, over the next 3 hours.

OTHER

Assessment of dietary compliance

Assessment of consumption of non-caloric artificial sweeteners

OTHER

Stool sampling

Subjects will provide a stool sample.

OTHER

Sodium Saccharin

Subjects in group 1 and group 3 will be provided with sodium saccharin.

OTHER

Placebo

Subjects in group 2 will be provided with placebo.

OTHER

Lactisole

Subjects in group 3 and group 4 will be provided with lactisole.

Sponsors & Collaborators

  • AdventHealth Translational Research Institute

    lead OTHER

Principal Investigators

  • Richard Pratley, MD · Translational Research Institute for Metabolism and Diabetes

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-01-26
Primary Completion
2018-03-21
Completion
2022-10-18

Countries

  • United States

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03032640 on ClinicalTrials.gov