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Pistachio Snacking and Metabolic Flexibility

NCT07340125 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2026-01-14

No results posted yet for this study

Summary

The purpose of this study is to evaluate the effects of pistachio snacking on metabolic flexibility (at rest, during exercise, and in post-exercise recovery) in healthy overweight and obese adults. Secondary goals include evaluating effects on changes in diet quality, sleep characteristics, physical activity, and hormonal health in women. In randomized order, participants will complete four days of pistachio snacking and four days of normal dietary habits (control). For both conditions, primary outcomes of resting substrate metabolism, metabolic flexibility during exercise, and post-exercise substrate metabolism will be measured pre-post intervention via indirect calorimetry. Secondary outcome of diet quality (kcal, carb, fat, protein) will be measured pre-post intervention via diet log. Exploratory outcomes of daily physical activity (steps, intensity), nightly sleep characteristics (quantity, quality, latency, efficiency), and daytime sleepiness and hunger.

Conditions

  • Overweight (BMI > 25)
  • Obese But Otherwise Healthy Participants
  • Overweight or Obese
  • Obese Patients (BMI ≥ 30 kg/m²)
  • Poor Sleep Quality
  • Healthy Participants
  • Physically Inactive

Interventions

OTHER

Pistachio

Roasted, lightly salted, pistachio kernels (no shell)

Sponsors & Collaborators

  • American Pistachio Growers

    collaborator OTHER

  • University of South Carolina

    lead OTHER

Principal Investigators

  • Katie R Hirsch, PhD · University of South Carolina

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
25 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-09-01
Primary Completion
2026-08-01
Completion
2026-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07340125 on ClinicalTrials.gov