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Effect of Different Concentrations of Xylitol and Erythritol on Gut Peptide Release and Gastric Emptying in Humans

NCT03039478 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 24

Last updated 2018-09-17

No results posted yet for this study

Summary

Xylitol and erythritol have become increasingly popular as sugar substitutes in the food industry. Both substances are freely available. While glucose ingestion stimulates satiation hormone secretion in the gut and slows down gastric emptying, artificial sweeteners such as aspartame, sucralose and acesulfame-K have no such effect. However, acute intake of 50g xylitol or 75g erythritol in 300mL tap water leads to a marked increase in the satiation hormones and induces a significant retardation in gastric emptying. The concentrations used to Show this effect were rather high (50g xylitol and 75g erythritol) and led to bloating and diarrhea in 60-70% of all subjects two hours after administration. The aim of the present study is to find an effective concentration of xylitol and erythritol still stimulating satiation hormone release without any gastrointestinal adverse events.

Conditions

  • Physiological Satiation Mechanisms

Interventions

DIETARY_SUPPLEMENT

Xylitol 7g

Xylitol 7g in 300mL tap water

DIETARY_SUPPLEMENT

Erythritol 10g

Erythritol 10g in 300mL tap water

DIETARY_SUPPLEMENT

Xylitol 17g

Xylitol 17g in 300mL tap water

DIETARY_SUPPLEMENT

Xylitol 35g

Xylitol 35g in 300mL tap water

DIETARY_SUPPLEMENT

Erythritol 25g

Erythritol 25g in 300mL tap water

DIETARY_SUPPLEMENT

Erythritol 50g

Erythritol 50g in 300mL tap water

Sponsors & Collaborators

  • University Hospital, Basel, Switzerland

    lead OTHER

Principal Investigators

  • Christoph Beglinger, Prof · University Hospital, Basel, Switzerland

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-02-24
Primary Completion
2018-08-31
Completion
2018-08-31

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03039478 on ClinicalTrials.gov