Acute Meat and Alternative Intake (PRotEin DIet SatisfacTION Trial 3)

Summary

Introduction: Protein rich foods that are alternatives to farm-grown meat have received considerable consumer attention. Whilst meat alternatives were once niche food products aimed at vegetarians, they are increasingly marketed to omnivores and "flexitarians", thus contributing to a trend for reductions in red meat intakes \[1\]. Studies to date have addressed the environmental benefit, plus consumer perceptions and acceptability of meat alternatives \[2, 3, 4\], yet there is surprisingly a paucity of data compared the nutritional and digestive differences to meat. The aim of this trial is to compare the digestive consequences of pasture-fed and grain-finished, beef versus a plant-based meat analogue blinded meal.

Methods and analyses: Healthy, young (20-34 y) participants will be asked to consume three separate meals in a crossover, blinded investigation followed by five hours of blood testing and questionnaires to assess the digestive consequences of meat and a plant-based meat analogue. The three meals will include either pasture-fed, or grain-finished, or laboratory based protein alternative as a mixed meal, in random order, separated by one week minimum. Plasma samples will be assessed amino acid content, neurotransmitter proteins, chylomicron fatty acid distribution and general health indices.

Ethics and dissemination: The trial has been granted ethical approval by the Ministry of Health, Health and Disability Ethics Committee (Ref: 19/STH/226). All results originating from this study will be submitted for publication in scientific journals and presented at meetings.

Conditions

• Diet, Healthy
• Protein; Disease

Interventions

OTHER

Food. Beef, Pasture-raised

Pasture-raised beef

OTHER

Food. Beef, Grain-fed

Grain-fed beef

OTHER

Food. Meat alternative

Meat alternative

OTHER

Food, Lamb

Lamb

Sponsors & Collaborators

• Institute for Human Development and Potential (IHDP), Singapore

  collaborator OTHER

• Massey University

  collaborator OTHER

• AgResearch

  collaborator UNKNOWN

• The Riddet Institute

  collaborator UNKNOWN

• University of Auckland, New Zealand

  lead OTHER

Principal Investigators

• Andrea J Braakhuis, PhD · The University of Auckland

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Model

CROSSOVER

Eligibility

Min Age

20 Years

Max Age

34 Years

Sex

MALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2020-11-01

Primary Completion

2021-01-30

Completion

2021-12-20

Countries

• New Zealand

Study Locations