Biomarkers of Meats and Potatoes Intake.

Summary

The discovery of biomarkers for the intake of meats and potatoes is needed for an accurate assessment of the intake of these foods. Twelve healthy subjects were enrolled in a controlled, cross-over meal study, randomized by a Latin square design. The test meals contained 1) beef, pork, chicken and a control meal for the meats and 2) french fries, boiled potatoes, chips and a control for the potato meals. A standardized diet was provided during sample collection. Blood and urine samples were collected up to 48h primarily for untargeted metabolomic profiling. Blood was further collected to study the effect of the meals on insulin and glycemic responses. Effects on satiety were measured by VAS and an ad libitum lunch following the test meals.

Conditions

• Biomarkers of Food Intake in Healthy Subjects

Interventions

OTHER

Meal sequence: 3C1A2B4D

Participants receive test meals in the sequence 3C1A2B4D

OTHER

Meal sequence: 2A3D4C1B

Participants receive test meals in the sequence 2A3D4C1B

OTHER

Meal sequence: 2D4B3A1C

Participants receive test meals in the sequence 2D4B3A1C

OTHER

Meal sequence: 3B2C1D4A

Participants receive test meals in the sequence 3B2C1D4A

OTHER

Meal sequence: 4C2B1A3D

Participants receive test meals in the sequence 4C2B1A3D

OTHER

Meal sequence:1B4D3C2A

Participants receive test meals in the sequence 1B4D3C2A

OTHER

Meal sequence:4A1C2D3B

Participants receive test meals in the sequence 4A1C2D3B

OTHER

Meal sequence:1D3A4B2C

Participants receive test meals in the sequence 1D3A4B2C

OTHER

Meal sequence: 4D3B2C1A

Participants receive test meals in the sequence 4D3B2C1A

OTHER

Meal sequence: 3A4C1B2D

Participants receive test meals in the sequence 3A4C1B2D

OTHER

Meal sequence: 1C2A3D4B

Participants receive test meals in the sequence 1C2A3D4B

OTHER

Meal sequence: 2B1D4A3C

Participants receive test meals in the sequence 2B1D4A3C

Sponsors & Collaborators

• University of Copenhagen

  lead OTHER

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Max Age

70 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2015-02-15

Primary Completion

2015-05-30

Completion

2015-05-30