Brain and Glycemic Responses to Sweet Soft Drinks

Summary

The goal of this observational study is to determine changes in brain activity and blood sugar in response to the ingestion of flavored waters sweetened with either the nutritive sugar sucrose or different low-caloric sweeteners in healthy normal-weight individuals aged between 18 and 30 years.

The main question it aims to answer is in how far brain and glycemic responses differ between a sugar-sweetened drink and drinks sweetened with different low-caloric sweeteners.

Participants will visit after an overnight fast six times and then have an MRI brain scan before and after consumption of 500 ml of one of the study drinks (beverage sweetened with sucrose or one of four non-caloric sweeteners, or water).

Conditions

• Normal Physiological Response to Sweet Drinks

Interventions

OTHER

Water (reference)

Ingestion of 500 ml mineral water

OTHER

Sucrose

Ingestion of 500 ml of a flavored mineral water sweetened with sucrose

OTHER

Sucralose

Ingestion of 500 ml of a flavored mineral water sweetened with sucralose

OTHER

Stevia

Ingestion of 500 ml of a flavored mineral water sweetened with stevia extract

OTHER

Monk fruit

Ingestion of 500 ml of a flavored mineral water sweetened with monk fruit extract

OTHER

Allulose + stevia

Ingestion of 500 ml of a flavored mineral water sweetened with allulose and stevia extract

Sponsors & Collaborators

• Tate & Lyle

  collaborator INDUSTRY

• Wageningen University

  lead OTHER

Principal Investigators

• Paul Smeets, PhD · Wageningen University

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

TRIPLE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Max Age

30 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2023-01-09

Primary Completion

2024-03-15

Completion

2024-03-15

Countries

• Netherlands

Study Locations