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Reduction of Sweetened Beverages and Intrahepatic Fat

NCT01394380 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 29

Last updated 2014-06-04

No results posted yet for this study

Summary

The study will enroll 68 overweight male and female subjects with a high (\> 2 3dl-can soda/day) consumption of sweetened beverage per day. After a run-in period of 4 weeks, subjects will be randomized to either a 12-week intervention arm in which sweetened beverages will be replaced by artificially sweetened, calorie-free beverages, or to a control arm. The following measurements will be performed at the end of the run-in period and at the end of the intervention period

* intrahepatic fat concentration
* visceral fat volume
* changes in day-long metabolic profile from baseline(plasma glucose, insulin, and triglyceride concentrations)
* changes in food intake and daily energy, carbohydrate and sugars intake from baseline

Conditions

Interventions

OTHER

artificially sweetened sodas

subjects will be allowed unlimited consumption of calorie-free, artificially-sweetened sodas, water, tea or coffee

Sponsors & Collaborators

  • Centre Hospitalier Universitaire Vaudois

    collaborator OTHER

  • Insel Gruppe AG, University Hospital Bern

    collaborator OTHER

  • University of Lausanne

    lead OTHER

Principal Investigators

  • Luc Tappy, MD · Department of Physiology, University of Lausanne

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-10-31
Primary Completion
2014-04-30
Completion
2014-04-30

Countries

  • Switzerland

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01394380 on ClinicalTrials.gov