Insulin resistance is a condition in which muscle, fat, and liver cells respond poorly to insulin, requiring the pancreas to produce more insulin to keep blood glucose controlled. Persistent insulin resistance can lead to prediabetes and type 2 diabetes when pancreatic compensation is no longer sufficient.
A study in Diabetologia shows type 2 diabetes in lean Africans is driven by insulin shortage, not insulin resistance, and may require different treatment than standard guidelines. The study analyzed data from over 3,300 African adults and found distinct complication patterns between lean and overweight patients.
A study in Life Metabolism shows that a single post-meal blood biomarker, 1-hour postprandial SPARC, predicts who benefits most from a Mediterranean diet. Lower baseline SPARC-1H levels were linked to greater improvements in insulin resistance and glucose control in a six-month trial.
Physician-supervised clinics in Florida and Texas offer semaglutide and tirzepatide weight loss programs. Clinical trials show average weight loss of 15% with semaglutide and about 21% with tirzepatide. All-inclusive monthly plans start at $349.
BrightGene Bio-Medical reported Phase III data for BGM0504 showing 19.3% mean weight reduction and improvements in blood pressure, lipids and uric acid. The data highlighted GIP as a key variable in broader metabolic management.
GLP-1 drugs used for type 2 diabetes and obesity are seeing rising demand for weight loss as safety concerns also draw attention. A 2025 WHO guideline said long-term safety data remains limited.
A Johns Hopkins study found GLP-1 users face increased dementia risk after a decade, possibly due to longer lifespan. A separate JCI review found GLP-1 drugs show neuroprotective signals in preclinical studies but consistent cognitive benefits in humans remain unproven.
Researchers have used a machine learning model called AI-IR to demonstrate that insulin resistance is a risk factor for 12 types of cancer. The tool analyzes nine clinical parameters from standard health checkups to predict insulin resistance at population scale. This provides the first large-scale evidence linking insulin resistance to multiple cancers.
GLP-1 receptor agonists like semaglutide and tirzepatide help regulate appetite and improve satiety for medical weight loss. Clinical studies show patients can lose an average of 15% of body weight with these treatments. These medications are suitable for individuals with BMI of 27+ with weight-related conditions or BMI of 30+ regardless of other conditions.
Veru Inc. has enrolled the first patient in its Phase 2b PLATEAU clinical trial evaluating enobosarm combined with semaglutide for weight loss in older patients with obesity. The study will assess enobosarm's ability to preserve lean mass and physical function while augmenting fat loss.
Semaglutide reduced osteoarthritis progression in obese mice through metabolic reprogramming of cartilage cells, independent of weight loss effects, according to research published in Cell Metabolism.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07778524 |
Alpelisib Challenge Test (ACT) |
NOT_YET_RECRUITING | PHASE1 |
| NCT07775326 |
Dietary Macronutrients and Metabolic Markers |
COMPLETED | NA |
| NCT07774208 |
FABP4 Response After Roux-en-Y Gastric Bypass |
COMPLETED | |
| NCT07770711 |
Inositol and Metformin Administration in Mediterranean Diet and Low-Carbohydrate Diets in Women With PCOS |
NOT_YET_RECRUITING | NA |
| NCT07770282 |
Efficacy and Safety of Semaglutide Versus Placebo on Cardiometabolic Profile in Patients With Schizophrenia With Metabolic Syndrome |
NOT_YET_RECRUITING | PHASE3 |
| NCT07736079 |
Evaluation of Serum Preptin Levels in Patients With Polycystic Ovary Syndrome |
NOT_YET_RECRUITING | |
| NCT07734558 |
Evaluation of Neuregulin-4 (NRG4) Levels in Obese and Non-Obese Patients With Type 2 Diabetes Mellitus |
NOT_YET_RECRUITING | |
| NCT07729280 |
Impact of Preoperative Oral Carbohydrate Loading on Insulin Resistance in Pediatric Cardiac Surgery Patients |
NOT_YET_RECRUITING | NA |
| NCT07724522 |
Prebiotic Inulin for Late-Reproductive Individuals |
RECRUITING | NA |
| NCT07712068 |
Effects of Exercise Sequence and Meal Sequence on Weight Management Among Children and Adolescents With Overweight or Obesity: The STEP Trial |
NOT_YET_RECRUITING | NA |
