Millets and Oats MRI

Summary

Breakfast porridges made from milled grains are commonly eaten worldwide. Traditionally different grains are used in different countries. For example, oats are more common in the Anglo-Saxon countries whilst millet is very common in parts of India and Africa. However the nutritional value of different grains and their potential effects on the body may vary dramatically: for example the effect on blood sugar, on how fast the stomach empties after eating and how full people may feel.

RESEARCH QUESTION: The investigators think that a pearl millet breakfast will cause a smaller rise in blood sugar compared with an oat breakfast containing the same number of calories. The investigators also think that there will be a difference in how full people feel and how fast their stomach will empty. These 2 breakfasts will be fed to each one of 26 healthy volunteers, one week apart. A safe medical imaging method (MRI) will be used to look at how quickly the breakfast empty from the stomach and how this affects the small bowel. Blood glucose levels will be measured using a finger prick test (the same as used by diabetics) and some small blood samples will be taken from a vein in the arm to measure the chemicals released by the gut after feeding gut hormones.

Conditions

• Healthy

Interventions

OTHER

Oats breakfast porridge

Isoenergetic and isovolumteric oats breakfast porridge

OTHER

Pearl (bajra) breakfast porridge

Isoenergetic and isovolumteric pearl (bajra) breakfast porridge

Sponsors & Collaborators

• University of Nottingham

  lead OTHER

Principal Investigators

• Jaber Alyami, MRes · Nottingham Digestive Disases Centre , University of Nottingham, Nottinghamshire, United Kingdom, NG7 2UH

• Luca Marciani · Nottingham Digestive Disases Centre , University of Nottingham, Nottinghamshire, United Kingdom, NG7 2UH

• Moira Taylor · School of Life Sciences, University of Nottingham, Nottinghamshire, United Kingdom, NG7 2UH

• Penny A Gowland · Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham NG7 2RD, U.K.

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Max Age

65 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2016-10-25

Primary Completion

2017-05-01

Completion

2017-05-01

Countries

• United Kingdom

Study Locations