Dried Fruit and Postprandial Glycemia Trial

Summary

Dried fruits show promising potential for the management of blood glucose. Previous trials have reported beneficial effects of raisins on post-prandial glucose and insulin responses in healthy individuals when compared with white bread. However, to date there is limited data evaluating the potential beneficial effects of other dried fruits (i.e. sultanas, dates and apricots). It is also unclear whether dried fruits can be used to lower the postprandial glycemic responses to high-GI carbohydrate foods by either displacing available carbohydrate (displacement effect) or providing 'catalytic' doses of fructose ('catalytic' fructose effect). To address these questions, the investigators propose to assess the GI of 4 common types of dried fruit (raisins, sultanas, dates, apricots) (GI effect) and their ability to decrease the postprandial glycemic response to white bread by either partially displacing available carbohydrate (displacement effect) or by providing a 'catalytic' dose of fructose ('catalytic' fructose effect).

Conditions

• PreDiabetes
• Diabetes Mellitus
• Dysglycemia

Interventions

OTHER

White Bread (Control)

A randomized multiple-crossover acute-feeding trial design. Each participant will act as their own control receiving the treatments in random order, each separated by a 1 day washout period.

OTHER

Dried Fruit - Glycemic Index

A randomized multiple-crossover acute-feeding trial design. Each participant will act as their own control receiving the treatments in random order, each separated by a 1 day washout period.

OTHER

Catalytic Fructose Dose Effect

A randomized multiple-crossover acute-feeding trial design. Each participant will act as their own control receiving the treatments in random order, each separated by a 1 day washout period.

OTHER

High GI Displacement Effect

A randomized multiple-crossover acute-feeding trial design. Each participant will act as their own control receiving the treatments in random order, each separated by a 1 day washout period.

Sponsors & Collaborators

• International Nut and Dried Fruit Council (INC)

  collaborator UNKNOWN

• The National Dried Fruit Trade Association (NDFTA)

  collaborator UNKNOWN

• Glycemia Consulting Inc.

  collaborator UNKNOWN

• University of Toronto

  lead OTHER

Principal Investigators

• John L Sievenpiper, MD PhD FRCPC · University of Toronto, St. Michael's Hospital

• Cyril Kendall, PhD · University of Toronto

Study Design

Allocation

RANDOMIZED

Masking

SINGLE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Max Age

75 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2016-11-30

Primary Completion

2016-12-31

Countries

• Canada

Study Locations