MedTrace Logo

Glycogen Storage Disease Breath Test Study

NCT03218904 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 14

Last updated 2025-01-27

No results posted yet for this study

Summary

Glycogen storage disease type I (GSD I) caused by deficiency of glucose-6-phosphatase enzyme leading to build up of a complex sugar called glycogen in liver and low blood glucose level. Nutritional treatment involves supplying carbohydrates and uncooked cornstarch. Glycosade® (modified cornstarch) has shown promise in maintaining normal blood glucose level in GSD I. But the difficulty in nutritional treatment is determining the best type of carbohydrate to be given to avoid low blood glucose. Thus, there is a need to develop a simple test to examine glucose digestion and measure the utilization of different carbohydrates in GSD I and healthy controls.

Conditions

  • Patient Compliance
  • Healthy

Interventions

DIETARY_SUPPLEMENT

Glucose intake

Experiment 1: study day1- single oral dose of glucose study day 2-single oral dose of glucose with U-13C-glucose

DIETARY_SUPPLEMENT

Carbohydrates intake

Experiment 2:study day1- single oral dose of uncooked cornstarch study day 2- single oral dose of Glycosade®

Sponsors & Collaborators

  • Saudi Arabian Cultural Bureau, Ottawa

    collaborator UNKNOWN

  • Canadian Institutes of Health Research (CIHR)

    collaborator OTHER_GOV

  • University of British Columbia

    lead OTHER

Principal Investigators

  • Rajavel Elango, PhD · University of British Columbia

Study Design

Allocation
NON_RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Model
SEQUENTIAL

Eligibility

Min Age
5 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-03-17
Primary Completion
2021-10-23
Completion
2025-01-24

Countries

  • Canada

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03218904 on ClinicalTrials.gov