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Incretin Effects of Branched Chain Amino Acids

NCT02697305 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 18

Last updated 2016-03-08

No results posted yet for this study

Summary

Branched chain amino acids (BCAA) are known to exert insulinogenic effect. Whether this effect is mediated by incretins (GLP-1, GIP) is not known. The aim of the study was to show incretin effect of BCAA, i.e. whether the oral administration of BCAA elicits higher insulin and incretin response when compared with IV route of the same dose of BCAA. Eighteen healthy, male subjects participated in three tests: IV application of BCAA solution (30.7±1.1 g of BCAA, IV BCAA) second was oral ingestion of BCAA capsules in the same dose (ORAL BCAA) and third experiment was oral placebo (PLACEBO). Glucose, insulin, GLP-1, GIP, valine, leucine and isoleucine levels were measured at time interval for up to 4 h.

Conditions

  • Glucose Metabolism Disorders

Interventions

DIETARY_SUPPLEMENT

IV BCAA

in total dose of 0,4 g/kg in a 2 h intravenous infusion

DIETARY_SUPPLEMENT

ORAL BCAA

single dose of 0.4g/kg administered over 30s washed down with 500mL of tap water

OTHER

ORAL Placebo

single dose of 0.4 g/kg administered over 30 s washed down with 500mL of tap water

Sponsors & Collaborators

  • Charles University, Czech Republic

    lead OTHER

Principal Investigators

  • Michal Anděl, Prof., MD · 3rd Faculty of Medicine, Charles University in Prague

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
30 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2014-09-30
Primary Completion
2015-05-31
Completion
2015-12-31

Countries

  • Czechia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02697305 on ClinicalTrials.gov