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Effects of an Amino-acid Supplement on Hepatic Lipid Metabolism

NCT01119989 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 9

Last updated 2018-05-04

No results posted yet for this study

Summary

10 healthy male volunteers will be studied after

* a 6 day weight maintenance, balanced diet
* a 6 days weight maintenance, balanced diet supplemented with 3 grams fructose/kg body weight/day
* a 6 days weight maintenance, balanced diet supplemented with 3 grams fructose/kg body weight/day and 20g amino-acids per day At the end of each 6 days period, the following measurements will be obtained
* intrahepatic lipids (1H-MRS)
* metabolic effects of fructose ingestion (measurement of substrate oxidation, gluconeogenesis from fructose, palmitate synthesis from fructose, plasma VLDL-kinetics)

This is a randomized, double blinded study

Conditions

  • Metabolic Syndrome

Interventions

DIETARY_SUPPLEMENT

Fructose+maltodextrin placebo

DIETARY_SUPPLEMENT

amino-acid + fructose

Sponsors & Collaborators

  • University of Bern

    collaborator OTHER

  • University of Lausanne

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
30 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-05-31
Primary Completion
2011-03-31
Completion
2011-12-31

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01119989 on ClinicalTrials.gov