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Milk Consumption and Blood Microbiome in Healthy Volunteers

NCT06944002 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 10

Last updated 2025-08-07

No results posted yet for this study

Summary

The goal of this study is to learn if cfDNA of milk-associated intestinal bacteria (MAIB) is detectable in the bloodstream. The primary question it aims to answer is:

\- Does milk consumption simultaneously increase the number of MAIB cfDNA counts in blood samples, as it does in fecal samples?

Researchers will compare cfDNA counts of MAIB to those of fecal samples to assess whether the blood microbiome is a valid measure of the gut microbiome, utilizing a self-developed bioinformatics pipeline.

Participants will:

* Abstain from consuming any dairy products for ten days, followed by drinking milk for 7 consecutive days.
* Provide blood and fecal samples before dairy abstinence, as well as at 0, 24, and 48 hours, and one week after the reintroduction of milk.

Conditions

  • Healthy

Interventions

DIETARY_SUPPLEMENT

Milk product

The participants will abstain from consumption of any dairy product for ten days and subsequently drink milk for seven consecutive days (700 ml per day), while concomitant consumption of other dairy products is also allowed.

Sponsors & Collaborators

Principal Investigators

  • Prof. Dr. Maikel P Peppelenbosch, MD, PhD · Erasmus Medical Center

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-07-10
Primary Completion
2025-09-15
Completion
2025-09-15

Countries

  • Netherlands

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06944002 on ClinicalTrials.gov