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Mapping the 'Sweet Brain' in Healthy Participants

NCT04162457 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 18

Last updated 2021-07-13

No results posted yet for this study

Summary

The human brain has a central role in regulating appetite and food intake. It integrates many metabolic, hedonic and trait-related signals that affect eating behaviour and determine when and how much we eat. The effects of non-nutritive sweeteners (NNS) that provide sweet taste with no calories on appetite, food intake thus weight status remain a subject of debate. In this study, the investigators aim to investigate whole brain response to the ingestion of beverages sweetened with caloric sugars (glucose, maltodextrin) or NNS (stevia) as well as neural substrates of attentional bias to food (pre-and post consumption) in healthy lean participants.

Conditions

Interventions

DIETARY_SUPPLEMENT

Stevia

Participants will be administered one of the study beverages at each one of the 4 imaging sessions.

DIETARY_SUPPLEMENT

Glucose

Participants will be administered one of the study beverages at each one of the 4 imaging sessions.

DIETARY_SUPPLEMENT

Maltodextrin

Participants will be administered one of the study beverages at each one of the 4 imaging sessions.

DIETARY_SUPPLEMENT

Water

Participants will be administered one of the study beverages at each one of the 4 imaging sessions.

Sponsors & Collaborators

  • Cargill

    collaborator INDUSTRY

  • University of Manchester

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-11-14
Primary Completion
2021-03-31
Completion
2021-03-31

Countries

  • United Kingdom

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04162457 on ClinicalTrials.gov