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Human Milk Oligossaccharide and Acetate Production in Vivo

NCT04795804 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 19

Last updated 2021-11-03

No results posted yet for this study

Summary

The study investigators hypothesize (1) that the SCFA/acetate metabolism differs between metabolic phenotypes and (2) that using a mixture of fibres that differ in degree of polymerization and branching namely a resistant starch and a human-like milk oligosaccharide enhance the acetate availability in the distal colon and systemic circulation, consequently leading to its metabolic effects.

To study this, the investigators will supplement lean, normoglycaemic vs. overweight/obese, prediabetic men with the fibre mixture the day before the clinical investigation day (CID) and study during the CID its effects on fasting and postprandial substrate and energy metabolism.

Conditions

Interventions

DIETARY_SUPPLEMENT

Human Milk Oligossaccharide

The day before the CIDs, the participants receive the supplements 3x a day in randomized order

DIETARY_SUPPLEMENT

Maltodextrin

The day before the CIDs, the participants receive the supplements 3x a day in randomized order

DIETARY_SUPPLEMENT

Human Milk Oligossaccharide and resistant starch

The day before the CIDs, the participants receive the supplements 3x a day in randomized order

Sponsors & Collaborators

  • Maastricht University Medical Center

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
30 Years
Max Age
65 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-02-04
Primary Completion
2021-10-15
Completion
2021-10-15

Countries

  • Netherlands

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04795804 on ClinicalTrials.gov