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The Omnibus Satiety Metric: Predicting Satiety in Humans Through Brain, Blood, and Subjective Data

NCT03900130 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 24

Last updated 2019-09-25

No results posted yet for this study

Summary

Designing food and drink that maximizes satiety has long been an ambition of industry and public health.

For obvious reasons, foods that fill faster and for longer are desirable to consumers for controlling their weight, and to public health programs that are designed to prevent obesity.

Current methods for measuring satiety have weak predictive value, commonly fail to replicate, and are yet to be validated with respect to energy consumption in everyday life.

The investigators propose to overcome this deficiency by developing the Omnibus Satiety Metric (OmniSaM).

OmniSaM is proposed as a multi-modal metric that targets the full spectrum of processes underlying the satiety cascade, composing brain, blood, mind and behavior of consumers.

As a proof-of-concept, subjects (normal BMI) will undergo a preload ad libitum paradigm, with a 2-parameter factorial design comparing milk based products differing in levels of caloric load and protein-to-carbohydrate ratio.

The investigators will acquire 1. high-resolution neuroimaging data, whilst 2. simultaneously recording appetitive hormones, 3. blood metabolite composition, 4. subjective sensory indices of appetite and 4. behavioral metrics of consumption.

Conditions

  • Satiation
  • Appetite
  • Behavior
  • Hunger

Interventions

DIETARY_SUPPLEMENT

Preload

In the 2 x 2 factorial design we vary two factors: 1. caloric load of the preload such that it is either high calorie or low. 2. protein to carbohydrate ratio of the preload such that it is either high or low

Sponsors & Collaborators

  • University of Copenhagen

    collaborator OTHER

  • Danish Research Centre for Magnetic Resonance

    collaborator OTHER

  • Derek Victor Byrne

    lead OTHER

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
20 Years
Max Age
40 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-10-18
Primary Completion
2019-04-01
Completion
2019-04-01

Countries

  • Denmark

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03900130 on ClinicalTrials.gov