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The Effects of Added Sugar Intake on Brain Blood Flow and Hippocampal Function in Midlife Adults

NCT05211726 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 44

Last updated 2025-06-12

Study results available
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Summary

This study will focus on improving brain health through dietary modification of added sugars in middle aged adults (50- 64 years old). Participants will be fed two 10-day diets (one diet containing 5% of total energy from added sugars and one diet containing 25% of total energy from added sugars) and examine blood vessel function, hippocampus structure using a MRI, and memory performance.

Conditions

  • Aging
  • Healthy Diet

Interventions

OTHER

Low Added Sugar Diet

Consumption of 10 days of a diet low in added sugars (5% of total caloric intake)

OTHER

High Added Sugar Diet

Consumption of 10 days of a diet high in added sugars (25% of total caloric intake)

Sponsors & Collaborators

  • National Institute of General Medical Sciences (NIGMS)

    collaborator NIH

  • University of Delaware

    lead OTHER

Principal Investigators

  • Christopher Martens, Ph.D. · University of Delaware

Study Design

Allocation
RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
50 Years
Max Age
64 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-01-11
Primary Completion
2024-05-03
Completion
2024-05-03

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05211726 on ClinicalTrials.gov