Identification of Biomarkers for Acute Intake of Beer and Alcohol and Acute Effects on Plasma and Insulin Response

Summary

The objective of the study is to identify biomarkers for acute intake of beer and alcohol in individuals with a high or low habitual intake. Furthermore, we wish to identify compounds and metabolites in different types of beer and alcohol, which can serve as compliance markers for intake under the test conditions (blood tests and urine samples). We also wish to determine the acute effects of these beverages on plasma glucose and insulin response, compared to regular soda.

Conditions

• Alcohol Consumption
• Insulin Resistance

Interventions

OTHER

Beverage sequence ABCD

Participants receive test beverages in the randomised order ABCD

OTHER

Beverage sequence CADB

Participants receive test beverages in the randomised order CADB

OTHER

Beverage sequence DACB

Participants receive test beverages in the randomised order DACB

OTHER

Beverage sequence CBAD

Participants receive test beverages in the randomised order CBAD

OTHER

Beverage sequence ABDC

Participants receive test beverages in the randomised order ABDC

OTHER

Beverage sequence DABC

Participants receive test beverages in the randomised order DABC

OTHER

Beverage sequence DCAB

Participants receive test beverages in the randomised order DCAB

OTHER

Beverage sequence DBCA

Participants receive test beverages in the randomised order BDCA

OTHER

Beverage sequence ADCB

Participants receive test beverages in the randomised order ADCB

OTHER

Beverage sequence BADC

Participants receive test beverages in the randomised order BADC

OTHER

Beverage sequence ACDB

Participants receive test beverages in the randomised order ACDB

Sponsors & Collaborators

• Carlsberg Breweries A/S

  collaborator UNKNOWN

• University of Copenhagen

  lead OTHER

Principal Investigators

• Lars O. Dragsted, Professor · Department of Nutrition, Exercise and Sports, University of Copenhagen, Rolighedsvej 30, 1958 Frederiksberg C, Denmark

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Max Age

60 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2013-05-31

Primary Completion

2013-06-30

Completion

2013-06-30

Countries

• Denmark