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Effect of Alcohol Consumption on Markers of Inflammation

NCT00918918 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 24

Last updated 2009-11-25

No results posted yet for this study

Summary

Rationale: High-density lipoprotein (HDL), which is consistently increased after moderate alcohol consumption, is an abundant plasma lipoprotein that is generally thought to be anti-inflammatory in both health and infectious disease. HDL binds and neutralizes the bioactivity of potent bacterial remnants such as lipopolysaccharides (LPS) which stimulate the host innate immune responses.

Primary objective: To explore whether prolonged moderate alcohol consumption affects in vivo cytokine response after a low dose of LPS in young, normal-weight men.

Conditions

Interventions

DIETARY_SUPPLEMENT

Alcohol + orange juice

100 mL Vodka (37.5 vol%; 30 gram of alcohol/day) + 200 mL orange juice

DIETARY_SUPPLEMENT

Orange juice

200 mL orange juice

Sponsors & Collaborators

  • TNO

    lead OTHER

Principal Investigators

  • Henk FJ Hendriks, PhD · TNO

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
21 Years
Max Age
40 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2009-08-31
Primary Completion
2009-11-30
Completion
2009-11-30

Countries

  • Netherlands

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00918918 on ClinicalTrials.gov