Alcohol Consumption and Circulating Metabolites

Summary

Alcohol consumption is a risk factor for numerous health conditions and an important cause of death. Identifying metabolites associated with alcohol consumption may provide insights into the metabolic pathways through which alcohol may affect human health. The objective of this study is to investigate associations of alcohol consumption with circulating concentrations of 123 metabolites including amino acids, acylcarnitines, hexoses, biogenic amines, phosphatidylcholines, and sphingomyelins. For this purpose, the investigators use data from the European Prospective Investigation into Cancer and Nutrition (EPIC) study and applied a discovery and replication approach.

Conditions

• No Condition, Focus: Metabolites of Alcohol Consumption

Sponsors & Collaborators

• Maastricht University

  collaborator OTHER

• Imperial College London

  collaborator OTHER

• Danish Cancer Society

  collaborator OTHER

• University of Aarhus

  collaborator OTHER

• Centre for Research in Epidemiology and Population Health (CESP)

  collaborator OTHER

• Gustave Roussy, Cancer Campus, Grand Paris

  collaborator OTHER

• German Cancer Research Center

  collaborator OTHER

• German Institute of Human Nutrition

  collaborator OTHER

• Hellenic Health Foundation

  collaborator OTHER

• Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

  collaborator OTHER

• ISPO Cancer Prevention and Research Institute

  collaborator UNKNOWN

• Federico II University

  collaborator OTHER

• HuGeF Foundation

  collaborator UNKNOWN

• Azienda Sanitaria Provinciale Ragusa

  collaborator OTHER

• University of Tromso

  collaborator OTHER

• Institut Català d'Oncologia

  collaborator OTHER

• Ministry of Health - Government of the Principality of Asturias

  collaborator OTHER_GOV

• Andalusian School of Public Health

  collaborator OTHER_GOV

• Universidad de Murcia

  collaborator OTHER

• Instituto de Salud Pública Gobierno de Navarra

  collaborator UNKNOWN

• Subdirección de Salud Pública de Gipuzkoa

  collaborator UNKNOWN

• Skane University Hospital

  collaborator OTHER

• Umeå University

  collaborator OTHER

• MORGEN-EPIC, Bilthoven

  collaborator UNKNOWN

• Prospect-EPIC, Utrecht

  collaborator UNKNOWN

• University of Oxford

  collaborator OTHER

• University of Cambridge

  collaborator OTHER

• International Agency for Research on Cancer

  lead OTHER

Eligibility

Min Age

30 Years

Max Age

70 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2012-10-24

Primary Completion

2016-10-26

Completion

2016-10-26