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Effect of Alcohol on Cephalic Phase Reflex and Gene Expression

NCT00652405 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 24

Last updated 2010-08-11

No results posted yet for this study

Summary

Moderate alcohol consumption has consistently been associated with lowered risk of developing type two diabetes mellitus compared to abstainers and heavy drinkers. However, the underlying mechanism for the lower risk of type two diabetes is not clear.

Hypothesis: moderate alcohol consumption for four weeks changes gene expression pathways of inflammatory status, insulin sensitivity and lipid and carbohydrate metabolism in adipose tissue in both lean and obese postmenopausal women.

Hypothesis: Oral sensory stimulation by means of alcohol in the oral cavity will induce a cephalic phase reflex as indicated by increased autonomic \& endocrine responses in postmenopausal women.

Conditions

Interventions

DIETARY_SUPPLEMENT

alcohol

250 ml of white wine (13% vol; \~25 gram of alcohol per day)

DIETARY_SUPPLEMENT

Placebo

250 ml of mineral water (Brand name: Vittel)

Sponsors & Collaborators

  • TNO

    lead OTHER

Principal Investigators

  • Henk FJ Hendriks, PhD · TNO

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Max Age
65 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2008-05-31
Primary Completion
2008-07-31
Completion
2008-07-31

Countries

  • Netherlands

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00652405 on ClinicalTrials.gov