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Moderate Alcohol Consumption, Fat and Carbohydrate Metabolism and Insulin Sensitivity

NCT00364767 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 19

Last updated 2008-05-23

No results posted yet for this study

Summary

Moderate alcohol consumption is associated with a decreased risk of diabetes type 2. This association could be mediated by an improvement of insulin sensitivity with moderate alcohol consumption. Patients with diabetes type 2 or impaired glucose tolerance often may have decreased fat oxidative capacity or oxidative phosphorylation in tissue such as muscle. This could lead to accumulation triglyceride storage in muscle, which could interfere with insulin signaling. Whether such mechanism can also play a role with moderate alcohol consumption is unknown and will be investigated in this study.

In addition, moderate alcohol consumption with a meal can lead to delayed hypoglycemia in type 1 diabetes patients. How moderate alcohol consumption affects postprandial glycemic response in healthy subjects is unknown. This is a secondary objective of this trial.

Conditions

Interventions

DIETARY_SUPPLEMENT

A

Alcohol consumption (32 g/day) for 4 weeks

DIETARY_SUPPLEMENT

B

Water

Sponsors & Collaborators

  • Dutch Foundation for alcohol research

    collaborator UNKNOWN

  • TNO

    lead OTHER

Principal Investigators

  • Henk FJ Hendriks, PhD. · TNO

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2004-10-31
Primary Completion
2004-12-31
Completion
2004-12-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00364767 on ClinicalTrials.gov