The Effect of Dietary Fibre and Plant Protein on Appetite and Metabolic Function

Summary

Acute effects on appetite and metabolic function have been observed for whole-grain rye cereal products. The aim of this study is to evaluate if the appetite suppressing effect of a whole-grain rye breakfast cereal may be further enhanced by the addition of fermentable dietary fibre and plant protein. The aim is also to try to elucidate how observed effects on subjective appetite are mediated in terms of changes in hormonal signals, flow of nutrients in the blood and products from bacterial fermentation of dietary fibre, and to relate this to the different composition of the breakfasts.

Conditions

• Appetite Regulation

Interventions

OTHER

Rye + high dose inulin + low dose gluten

In a randomized cross-over design each subject receive one of six iso-caloric breakfasts on six different occasions, separated by 1 w wash-out.

OTHER

Rye + equal doses of inulin & gluten

In a randomized cross-over design each subject receive one of six iso-caloric breakfasts on six different occasions, separated by 1 w wash-out.

OTHER

Rye + low dose inulin + high dose gluten

In a randomized cross-over design each subject receive one of six iso-caloric breakfasts on six different occasions, separated by 1 w wash-out.

OTHER

Large non-supplemented rye

In a randomized cross-over design each subject receive one of six iso-caloric breakfasts on six different occasions, separated by 1 w wash-out.

OTHER

Small non-supplemented rye

In a randomized cross-over design each subject receive one of six iso-caloric breakfasts on six different occasions, separated by 1 w wash-out.

OTHER

Refined wheat bread

In a randomized cross-over design each subject receive one of six iso-caloric breakfasts on six different occasions, separated by 1 w wash-out.

Sponsors & Collaborators

• Uppsala University

  collaborator OTHER

• Swedish University of Agricultural Sciences

  lead OTHER

Principal Investigators

• Rikard K Landberg, Ass. Prof. · Swedish University of Agricultural Sciences

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Max Age

60 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2013-03-31

Primary Completion

2013-08-31

Completion

2013-08-31

Countries

• Sweden

Study Locations