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Grain Fibre and Gut Health

NCT03550365 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2018-06-20

No results posted yet for this study

Summary

Wholegrain fibre is known to affect on the gut health, but also may cause intestinal discomfort. Thus, many individuals may avoid the consumption of whole grain cereals in spite of their known health benefits, and may in this regard consume more restricted diets. In the preset study the aim was to technologically modify the cereal fibres to improve its usability and to maintain its health beneficial properties. The objective was to investigate intestinal fermentation of grain dietary fibre and associated effects on gut-mediated metabolic health, such as immunological health and adipose tissue function. The hypothesis was that whole grain products maintain their original beneficial health effects and may be better tolerable when the bran is technologically modified. Additionally, it was hypothesized that gut-mediated bioavailability of plant cell wall compounds and their metabolites affect the metabolic health through their immunomodulatory effects.

Conditions

  • Intestinal Disorder
  • Glucose Metabolism Disorders
  • Inflammation

Interventions

OTHER

Rye bran bread intervention

4 week dietary intervention rich in rye bran bread

OTHER

Rye bread intervention

4 week dietary intervention rich in rye bread

OTHER

Wheat bread diet

4 week dietary intervention rich in wheat bread as an active comparator for previous two interventions

Sponsors & Collaborators

  • VTT Technical Research Centre of Finland

    collaborator OTHER

  • University of Eastern Finland

    lead OTHER

Principal Investigators

  • Marjukka Kolehmainen, Professor · University of Eastern Finland

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
30 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2011-01-01
Primary Completion
2012-12-31
Completion
2017-12-31

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Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03550365 on ClinicalTrials.gov