Influence of Dietary Fiber-rich Meals on Gene Expression and Postprandial Glucose and Lipid Response

Summary

The aim of this study is to

* Measure the effect on gene expression in leukocytes from a meal rich in oat bran
* Investigate the postprandial glucose, insulin and triglyceride responses after intake of meals containing fiber from different sources (oat, rye and sugar beet fiber) or a meal containing a mixture of these three fibers

Conditions

• Hypoglycemia
• Hyperglycemia

Interventions

OTHER

Oat bran

82 g oat bran was added to 250 ml blackcurrant beverage with pulp to give 5 g soluble fiber (12.6 g total fiber).

OTHER

Spray-dried oat drink

62 g spray-dried oat drink was added to 250 ml blackcurrant beverage with pulp to give 2.7 g soluble fiber (3.3 g total fiber).

OTHER

Rye bran

31 g rye bran was added to 250 ml blackcurrant beverage with pulp to give 1.7 g soluble fiber (12 g total fiber).

OTHER

Sugar beet fiber

19 g sugar beet fiber was added to 250 ml blackcurrant beverage with pulp to give 5 g soluble fiber (12 g total fiber).

OTHER

Mixture of fiber

38 g spray-dried oat drink, 30 g rye bran and 6 g sugar beet fiber were added to 250 ml blackcurrant beverage with pulp to give 5 g soluble fiber (18 g total fiber).

OTHER

Control

No fiber was added to control meal (250 g black-currant beverage)

Sponsors & Collaborators

• Vinnova

  collaborator OTHER_GOV

• Oatly AB

  collaborator UNKNOWN

• Lantmannen Food R&D

  collaborator UNKNOWN

• Danisco Sugar AB/Fibrex

  collaborator UNKNOWN

• Lund University

  lead OTHER

Principal Investigators

• Gunilla Önning, Dr. · Lund University

Study Design

Allocation

RANDOMIZED

Masking

SINGLE

Model

FACTORIAL

Eligibility

Min Age

20 Years

Max Age

65 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2007-05-31

Primary Completion

2007-06-30

Completion

2007-06-30

Countries

• Sweden

Study Locations