The Effects of Quinoa and Buckwheat on Weight Management and Gut Microbiome

Summary

This study aims to compare the effects of quinoa, buckwheat, rice, and bulgur consumption on dietary intake, anthropometric measurements, glycemic response, lipid profile, inflammatory markers, blood pressure, and intestinal microbiome in people with overweight and obesity. The primary hypotheses of the studies were given as follows:

Hypothesis 1:

H1: In people with overweight and obesity, the addition of quinoa and buckwheat to the diet provides weight loss.

H0: In people with overweight and obesity, the addition of quinoa and buckwheat to the diet does not provide body weight loss.

Hypothesis 2:

H2: In people with overweight and obesity, the addition of quinoa and buckwheat to the diet affects glycemic response.

H0: In people with overweight and obesity, the addition of quinoa and buckwheat to the diet does not affect glycemic response.

Hypothesis 3:

H3: In people with overweight and obesity, the addition of quinoa and buckwheat to the diet affects the blood lipid profile.

H0: In people with overweight and obesity, the addition of quinoa and buckwheat to the diet does not affect the blood lipid profile.

Hypothesis 4:

H4: In people with overweight and obesity, the addition of quinoa and buckwheat to the diet changes the composition of the gut microbiome.

H0: In people with overweight and obesity, the addition of quinoa and buckwheat to the diet does not change the composition of the gut microbiome.

Hypothesis 5:

H5: In people with overweight and obesity, the addition of quinoa and buckwheat to the diet increases alpha diversity in the intestinal microbiome.

HO: In people with overweight and obesity, the addition of quinoa and buckwheat to the diet does not increase alpha diversity in the intestinal microbiome.

Hypothesis 6:

H6: In people with overweight and obesity, the addition of quinoa and buckwheat to the diet increases beta diversity in the intestinal microbiome.

HO: In people with overweight and obesity, the addition of quinoa and buckwheat to the diet does not increase beta diversity in the intestinal microbiome.

Conditions

• Overweight
• Obesity

Interventions

DIETARY_SUPPLEMENT

quinoa

Participants consumed 40 g/d red quinoa during 4 weeks. Participants were instructed to consume red quinoa by boiling it without any other ingredients.

DIETARY_SUPPLEMENT

Buckwheat

Participants consumed 40 g/d of buckwheat during 4 weeks. Participants were instructed to consume buckwheat by boiling it without any other ingredients.

DIETARY_SUPPLEMENT

Rice

Participants consumed 40 g/d rice during 4 weeks. Participants were instructed to consume rice by boiling it without any other ingredients.

DIETARY_SUPPLEMENT

Bulgur wheat

Participants consumed 40 g/d of bulgur wheat during 4 weeks. Participants were instructed to consume bulgur wheat by boiling it without any other ingredients.

Sponsors & Collaborators

• Hacettepe University

  lead OTHER

Principal Investigators

• Zehra Buyuktuncer, Prof. Dr. · Hacettepe University

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

25 Years

Max Age

45 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2024-01-24

Primary Completion

2025-01-17

Completion

2025-02-08

Countries

• Turkey (Türkiye)

Study Locations