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SweetSpot - The Effect of Non-nutritive Sweeteners on Health

NCT07361406 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2026-02-27

No results posted yet for this study

Summary

The aim of the study is to investigate the effect of non-nutritive sweeteners on glucose regulation. Secondary objectives are to investigate the effect of NNS on gut microbiome, gut hormone secretion, sweet taste sensitivity and preference, and the excretion of NNS in urine.

Conditions

  • Healthy Adult

Interventions

OTHER

Diet with non-nutritive sweeteners

Fully controlled diet with added mixture of non-nutritive sweeteners. The mixture consist of 6 different non-nutritive sweeteners: acesulfame-K, aspartame, cyclamate, saccharin, sucralose, and rebaudioside A (stevia).

OTHER

Diet without non-nutritive sweeteners

Fully controlled diet without any non-nutritive sweeteners added.

Sponsors & Collaborators

  • Food & Biobased Research - Wageningen UR

    collaborator UNKNOWN

  • TKI Agri & Food

    collaborator UNKNOWN

  • The Magnum Ice Cream Company

    collaborator UNKNOWN

  • Tate & Lyle

    collaborator INDUSTRY

  • Symrise AG

    collaborator UNKNOWN

  • American Beverage Association

    collaborator OTHER

  • Yildiz Holding

    collaborator UNKNOWN

  • Wageningen University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
45 Years
Max Age
79 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-02-23
Primary Completion
2026-11-26
Completion
2026-11-26

Countries

  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07361406 on ClinicalTrials.gov