Impacts of Fermented Oat-based Product on Gut Microbiota and Health

Summary

This study aims to investigate the effects of consuming fermented oat-based products on gut and overall human health. It is a randomized, controlled, cross-over trial with a dietary intervention.

A total of 100 participants will be enrolled in this study and they will eat both fermented and unfermented oat-based products for three weeks. Participants will eat their habitual diet between the dietary intervention periods (wash-out).

During the study, participants' perceived health, inflammatory markers, glucose and lipid metabolism, tryptophan metabolites, gastrointestinal symptoms, and gut microbiota will be assessed.

Conditions

• Metabolic Syndrome

Interventions

OTHER

Fermented oat-based product

Participants will incorporate a novel fermented product into their habitual diet for three weeks. In addition, the consumption of dairy and plant-based dairy alternatives is restricted. Cereal product consumption, specifically bread and porridge, is slightly restricted to prevent gastrointestinal symptoms caused by the increased intake of dietary fibre. Participants will receive dietary guidance on how to follow the intervention diet, as well as potential supplement recommendations provided by the authorized nutritionist.

OTHER

Unfermented oat-based product

Participants will incorporate a novel unfermented product into their habitual diet for three weeks. Dietary adjustments and other guidance are consistent with those described during the fermented product intervention.

Sponsors & Collaborators

• University of Turku

  collaborator OTHER

• Umeå University

  collaborator OTHER

• ETH Zurich

  collaborator OTHER

• KU Leuven

  collaborator OTHER

• University of Eastern Finland

  lead OTHER

Principal Investigators

• Marjukka Kolehmainen · Professor

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Model

CROSSOVER

Eligibility

Min Age

30 Years

Max Age

65 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2024-01-22

Primary Completion

2024-12-18

Completion

2024-12-18

Countries

• Finland

Study Locations