Impacts of Fermented Pea- and Legume-based Product on Gut Microbiota and Health

Summary

This study aims to investigate the effects of consuming fermented pea- and legume-based product on gut and overall human health. It is a randomized, single-blinded, controlled, cross-over trial with a dietary intervention.

A total of 100 participants will be enrolled in this study and they will eat both fermented and unfermented pea- and legume-based products for three weeks. Participants will eat their habitual diet between the dietary intervention periods (wash-out).

During the study, participants' perceived health, inflammatory markers, glucose and lipid metabolism, tryptophan metabolites, gastrointestinal symptoms, and gut microbiota will be assessed.

Conditions

• Metabolic Syndrome

Interventions

OTHER

Fermented meat alternative

Participants incorporate a novel fermented product into their habitual diet for three weeks. The product replaces the main protein source of the meal(s). Participants will receive dietary guidance on how to follow the intervention diet, as well as potential supplement recommendations provided by the authorized nutritionist.

OTHER

Unfermented meat alternative

Participants incorporate an unfermented product into their habitual diet for three weeks. The product replaces the main protein source of the meal(s). Participants will receive dietary guidance on how to follow the intervention diet, as well as potential supplement recommendations provided by the authorized nutritionist.

Sponsors & Collaborators

• University of Turku

  collaborator OTHER

• Umeå University

  collaborator OTHER

• KU Leuven

  collaborator OTHER

• Flemish institute of biotechnology (VIB)

  collaborator OTHER

• ETH Zurich

  collaborator OTHER

• University of Eastern Finland

  lead OTHER

Principal Investigators

• Marjukka Kolehmainen · University of Eastern Finland

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Model

CROSSOVER

Eligibility

Min Age

30 Years

Max Age

70 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2025-01-14

Primary Completion

2025-12-12

Completion

2025-12-12

Countries

• Finland

Study Locations