Promephy - Metabolic Fate of Plant-based Proteins

Summary

The PROMEPHY study aims to assess differences between animal versus plant-based proteins on metabolic and physiological parameters in healthy adults. It is envisaged that the results from this study will provide important and novel insights into the potential health-benefits of regular consumption of plant-based proteins. This may enable future application in products available to the consumer.

The main objective of this study is to compare the changes in serum essential amino acid bioavailability after two weeks of daily consumption of a plant-based protein mix with the changes in serum essential amino acid bioavailability after two weeks of daily consumption of a milk protein isolate. In addition this study will aim to assess the impact of different protein sources on gut microbiota and proteome composition to determine the potential health impact of consumption of plant-based proteins.

Conditions

• Amino Acid Change
• Gastrointestinal Dysfunction

Interventions

DIETARY_SUPPLEMENT

Dairy based protein

Initial bioavailability trial, followed by 2 weeks consumption of product and follow up bioavailability trial

DIETARY_SUPPLEMENT

Mixed protein

Initial bioavailability trial, followed by 2 weeks consumption of product and follow up bioavailability trial

DIETARY_SUPPLEMENT

Plant-based protein 1

Initial bioavailability trial, followed by 2 weeks consumption of product and follow up bioavailability trial

DIETARY_SUPPLEMENT

Plant-based protein 2

Initial bioavailability trial, followed by 2 weeks consumption of product and follow up bioavailability trial

Sponsors & Collaborators

• Danone Nutricia Research

  collaborator INDUSTRY

• Anglia Ruskin University

  lead OTHER

Principal Investigators

• Justin Roberts, PhD · Anglia Ruskin University

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Max Age

50 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2023-05-02

Primary Completion

2024-02-17

Completion

2024-02-17

Countries

• United Kingdom

Study Locations