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Independent Effects of High-cholesterol (High-egg) and High-saturated Fat Diets on LDL-cholesterol

NCT05267522 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 77

Last updated 2023-12-13

No results posted yet for this study

Summary

This study will comprise a randomized controlled, counter-balanced, cross-over trial to evaluate the independent effects of a high cholesterol (high egg), low saturated fat diet and a high saturated fat, low cholesterol diet on blood lipids. Evaluations also include analysis of physical activity as there is emerging evidence that the lutein and zeaxanthin in egg yolk may increase physical activity levels by crossing the blood-brain barrier and altering neuronal function. The study will also investigate effects on a number of novel lipoprotein parameters (particle size and particle concentrations).

Conditions

Interventions

OTHER

Egg diet

30% fat \[6% saturated fat\], 20% protein, 40% carbohydrate, 600 mg cholesterol

OTHER

Egg-free Diet

30% fat \[12% saturated fat\], 25% protein, 40% carbohydrate, 300 mg cholesterol

OTHER

Control Diet

30% fat \[12% saturated fat\], 25% protein, 40% carbohydrate, 600 mg cholesterol

Sponsors & Collaborators

  • American Egg Board

    collaborator OTHER

  • University of South Australia

    lead OTHER

Principal Investigators

  • Jonathan D Buckley, PhD · University of South Australia

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-03-01
Primary Completion
2023-08-10
Completion
2023-08-31

Countries

  • Australia

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05267522 on ClinicalTrials.gov