Polymorphisms in CD36 and STAT3 Genes and Different Dietary Interventions Among Patients With Coronary Artery Disease

Summary

Background: Cardiovascular diseases are the major health problem worldwide and the understanding of genetic contributions on the development of cardiovascular diseases is increasing significantly. The CD36 is a protein associated with uptake of oxidized forms of LDL and the single nucleotide polymorphism (SNP) rs1761667 A/G in the CD36 gene is correlated with increased consumption of total fat. The transcription factor STAT3 is released during the inflammatory acute phase response and the SNP rs8069645 G/A in the STAT3 gene is associated with abdominal obesity and higher intake of saturated fat. Studies have been shown the benefits of the Mediterranean diet in secondary prevention of cardiovascular disease and these dietary patterns have been often studied with nutrigenetic approach; these studies, however, are often limited to European populations, making it difficult to generalize to different populations.

Hypothesis: Different dietary approaches may similarly influence in modifying metabolic, inflammatory and anthropometric profile, especially among patients with coronary arterial disease (CAD). The genetic interaction with environmental factors such as the nutrient intake, and the prescription of a different diet according to individual genotype, could influence the development and/or the treatment of cardiovascular diseases.

Objective: To evaluate the effect of three dietary approaches on metabolic, inflammatory and anthropometric profile in patients with CAD and possible interactions with polymorphisms in CD36 and STAT3 genes.

Conditions

• Coronary Artery Disease

Interventions

DIETARY_SUPPLEMENT

Olive oil

30ml a day of olive oil

DIETARY_SUPPLEMENT

Nuts

30g a day of nuts

DIETARY_SUPPLEMENT

Control diet

Diet based on standard guidelines

Sponsors & Collaborators

• Conselho Nacional de Desenvolvimento Científico e Tecnológico

  collaborator OTHER_GOV

• Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul, Brazil

  collaborator OTHER

• Instituto de Cardiologia do Rio Grande do Sul

  lead OTHER

Principal Investigators

• Aline Marcadenti, PhD · Instituto de Cardiologia/Fundação Universitária de Cardiologia (IC/FUC)

• Vera L Portal, PhD · Instituto de Cardiologia/Fundação Universitária de Cardiologia (IC/FUC)

• Melissa M Markoski, PhD · Instituto de Cardiologia/Fundação Universitária de Cardiologia

• Alexandre S Quadros, PhD · Instituto de Cardiologia/Fundação Universitária de Cardiologia

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

40 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2014-08-31

Primary Completion

2016-06-17

Completion

2020-12-31

Countries

• Brazil

Study Locations