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Assessment of TMAO Formation With Egg Intake Versus Choline Supplement in a Healthy Population

NCT03142763 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2019-01-07

No results posted yet for this study

Summary

The objective of this study is to determine the effects of consuming either 3 eggs per day as compared to a daily choline supplement (choline bitartrate, 397.5 mg choline/day) on plasma concentrations of High Density Lipoprotein-cholesterol (HDL-C), trimethylamine N-oxide (TMAO), and other biomarkers of cardiovascular disease risk in young, healthy individuals. The goal is to determine if choline given as phosphatidylcholine (eggs) will lead to a different TMAO response when compared to choline in free supplemental form.

Conditions

  • Cardiovascular Risk Factor

Interventions

OTHER

Eggs

Consumption of 3 eggs per day for breakfast, 4 weeks

DIETARY_SUPPLEMENT

Choline Supplement

Consumption of choline supplement, 1 1/2 tablet (395mg choline), with breakfast for 4 weeks

Sponsors & Collaborators

  • University of Connecticut

    lead OTHER

Principal Investigators

  • Maria Luz Fernandez, PhD · University of Connecticut

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
30 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-01-31
Primary Completion
2018-04-30
Completion
2018-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03142763 on ClinicalTrials.gov