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Postprandial Effects of Milk Fats

NCT04178681 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2019-11-26

No results posted yet for this study

Summary

Nowadays, mostly vegetable fat blends are used in infant formula, but the use of bovine milk fat is increasing. In terms of fat structure, bovine milk fat and vegetable fats differ. Bovine milk fat has a higher percentage of palmitic acid attached to the sn-2 position of the glycerol backbone compared to vegetable fat blend. Also bovine milk fat contains milk fat globular membranes, as opposed to vegetable fat. With this study the investigators want to examine the effects of a vegetable fat blend versus bovine milk fat without globular membranes and bovine milk fat with globular membranes on underlying mechanistic, immune and metabolic responses.

Conditions

  • Genomics
  • Postprandial Metabolism
  • Nutrition
  • Metabolism

Interventions

OTHER

100% vegetable blend

Dietary lipid challenge test: 600 ml skimmed milk plus 95 gram of vegetable fat blend.

OTHER

100% AMF

Dietary lipid challenge test: 600 ml skimmed milk plus 95 gram of anhydrous milk fat.

OTHER

100% cream

Dietary lipid challenge test: 600 ml skimmed milk plus 95 gram of anhydrous milk fat plus milk fat globular membranes.

Sponsors & Collaborators

  • Friesland Campina

    collaborator UNKNOWN

  • Wageningen University

    lead OTHER

Principal Investigators

  • Lydia Afman, PhD · Wageningen University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
40 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-12-02
Primary Completion
2020-02-28
Completion
2020-02-28

Countries

  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04178681 on ClinicalTrials.gov